Raman Spectroscopic Systems

Raman Spectroscopic Systems

Endress+Hauser’s Raman spectroscopic systems combine embedded analyzers with fiber‑optic probes to deliver in situ, real‑time identification and quantification of chemical composition from lab to full‑scale production. The portfolio spans instruments and optics for liquids, slurries, gases, and solids, with industrial data interfaces (OPC UA, Modbus TCP/RS‑485, Ethernet web server, USB) for straightforward integration into control and data‑historian environments.

Raman provides molecule‑specific “fingerprints” without reagents or sample transport, enabling faster decisions and fewer offline assays. In gas applications it measures even homonuclear diatomics (H₂, N₂, O₂), and modern designs minimize consumables compared to chromatographs; multi‑stream capability further reduces analyzer count. Together these benefits raise availability and shrink lifecycle cost.

Analyzer lineup: Raman Rxn2 is the bridge from laboratory to plant, benchtop or cart‑mounted, with model‑transfer workflows for development and scale‑up. Raman Rxn4 is the rugged 24/7 process platform featuring self‑monitoring/diagnostics, self‑calibration, 19‑inch rack stacking, and an optional stainless NEMA 4X field enclosure. Raman Rxn5 is a turn‑key process analyzer optimized for quantitative gas‑phase measurement with a compact, serviceable design for hazardous areas. All are powered by Kaiser Raman technology and offered at 532, 785, and 1000 nm (model‑dependent).

Probe families cover every sampling geometry. The versatile Rxn‑10 accepts interchangeable optics, immersion and non‑contact heads for liquids/solids, plus bioprocess‑oriented options, so one probe can support multiple unit operations and development rigs. Materials and wavelength sets match common chemistries and fluorescence constraints.

Application‑specific probes extend coverage: Rxn‑20 delivers focus‑free, non‑contact solids measurements over large areas for representative results on tablets, pellets, foods, and powders (ATEX/CSA/IECEx/UKCA/JPEx). Rxn‑30 addresses headspace and gas streams with direct insertion up to 150 °C and 68.9 barg (1,000 psig) and hazardous‑area approvals. Rxn‑40 is a sealed immersion probe for liquids with NeSSI‑compatible flow options and a wide range of process connections and wetted materials (e.g., C276, 316L, and titanium).

Bioprocessing solutions are comprehensive. bIO‑Optics fit standard reactor ports for robust upstream control; the bio sleeve enables automatic alignment and reduces cross-contamination risk; and a Raman optic system for single‑use brings cGMP-qualified, gamma-sterilizable capability to SUBs. The Rxn‑46 bioprocess probe integrates with Sartorius BioPAT® Spectro platforms, and a Raman flow assembly (flow bench + micro flow cell) supports fast, low‑turbidity downstream steps such as chromatography.

Software completes the workflow. Embedded Raman RunTime simplifies 24/7 analyzer operation (local touchscreen or remote), while Raman Data Library centralizes spectral data with real‑time import, project organization, and cGxP features such as user management, e‑signatures, and audit trails for compliant reporting.

For system design, the portfolio scales from single points to multi‑channel architectures: Rxn analyzers support multiple probes, and Rxn5 can measure four streams simultaneously for faster results. Standard industrial protocols and hazardous‑area certifications across analyzers and probes streamline engineering, cybersecurity hardening, and validation.

Typical applications include reaction monitoring, endpoint detection, and blend verification in chemicals and polymers; PAT/QbD monitoring of cell culture, fermentation, and crystallization in life sciences; gas‑phase composition in hydrogen, ammonia, reformers, and turbine feeds; and solids quality checks in food processes. The same platforms support model transfer from Rxn2 development to Rxn4/Rxn5 production, preserving methods while improving time‑to‑value.

Vector, your Authorized Endress+Hauser Representative